布朗大学肿瘤纳米医学博士,
美国爱默蕾(Emory)大学 现任职务 Nancy Panoz终身讲座教授
发表SCI期刊发表文章 100篇,被他引 4775次 (SCI数据库), H-因子(H-index):28 (SCI数据库),其中单篇引高1156次、第-和通讯作者单篇引高311次。合作编著作 8 本。获得美国专利 2 项,另有5项专利已被美国专利局初步批准(准专利),即将最后批准。主持美国国立卫生研究院科学基金等项目18 项,负责经费总额 2000多万美元,约合人民币总计 1亿3000多万元。 现每年度获美国国立卫生研究院科学基金专项拨款130万美元,约合人民币900多万元。
部分代表性论文
1. Gao N, Bozeman EN, Qian W, Wang L, Chen HY, Lipowska M, Staley CA, Y. Andrew Wang YA, Mao Hui, and Yang L* Tumor Penetrating Theranostic Nanoparticles for Enhancement of Targeted and Image-guided Drug Delivery into Peritoneal Tumors following Intraperitoneal Delivery. Theranostics, 2017, 10;7(6):1689-1704. ( Journal impact factor:8.7) *Corresponding Author
2. Wang L, Huang, Chen H, Wu H, Xu Y, Li Y, YiH, Wang YW, Yang L and Mao H. Exerting Enhanced Permeability and Retention Effect Driven Delivery by Ultrafine Iron Oxide Nanoparticles with Switchable Magnetic Resonance Imaging Contrast. ACS Nano 2017, 11(5) 4582-4592. (Journal impact factor:13.3)
3. Huang, J., Li, Y., Orza, A., Lu, Q., Guo, P., Wang, L., Yang, L.* and Mao, H.*, Magnetic Nanoparticle Facilitated Drug Delivery for Cancer Therapy with Targeted and Image‐Guided Approaches. Advanced Functional Materials, 2016, 26(22) 3818-3836. (引用次数: 16, Journal impact factor:11.80). *Corresponding Author
4. Yang E, Qian W, Cao Z, Wang L, Bozeman EN, Ward C, Yang B, Selvaraj P, Lipowska M, Wang YA, Mao H, Yang L*. Theranostic Nanoparticles Carrying Doxorubicin Attenuate Targeting Ligand Specific Antibody Responses Following Systemic Delivery. Theranostics, 2015, 5(1):43-61. (引用次数:9, Journal impact factor:8.7) *Corresponding Author
5. Zhou, H., W. Qian, F. M. Uckun, L. Wang, Y. A. Wang, H. Chen, D. Kooby, Q. Yu, M. Lipowska and C. A. Staley, Mao H and Yang L*. IGF1 Receptor Targeted Theranostic Nanoparticles for Targeted and Image-Guided Therapy of Pancreatic Cancer. ACS Nano, 2015, 9(8):7976-91. (引用次数: 16, Journal impact factor:13.3) *Corresponding Author
6. Yang L*, Sajja HK, Cao Z, Qian W, Bender L, Marcus AI, Lipowska M, Wood WC, and Wang YA. uPAR-targeted Optical Imaging Contrasts as Theranostic Agents for Tumor Margin Detection. Theranostics, 2014, 4(1): 106–118. (引用次数:22, Journal impact factor:8.7) *Corresponding Author
7. Xi L, Satpathy, M Zhao, Q Qian, W, Yang L, Jiang H. HER-2/neu targeted delivery of a nanoprobe enables dual photoacoustic and fluorescence tomography of ovarian cancer. Nanomedicine: Nanotechnology, Biology and Medicine, 2014, 10(3):669-77. (引用次数:13, Journal impact factor:6.69)
8. Lee GY, Qian W, Wang L, Wang YA, Staley CA, Nie S, Mao H, and Yang L*. Theranostic Nanoparticles with Controlled Release of Gemcitabine for Targeted Therapy and MRI of Pancreatic Cancer, ACS Nano, 2013, 26;7(3):2078-89.(引用次数: 100, Journal impact factor:13.3) *Corresponding Author
9. Satpathy M, Wang L, Zielinski R, Qian W, Lipowska M, Capala J, Lee G, Xu H, Wang AY, Mao H, Yang L*. Active Targeting Using HER-2-affibody-conjugated Nanoparticles Enabled Sensitive and Specific Imaging of Orthotopic HER-2 Positive Ovarian Tumors. Small, 2013, 12;10 (3):544-55. (引用次数:28, Journal impact factor:8.37) *Corresponding Author
10. Xu H, Aguilar ZP, Yang L, Kuang M, Duan H, Xiong Y, Wei H, and Wang A. Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood. Biomaterials, 2011; 32(36):9758-65. (引用次数: 87, Journal impact factor:8.56)
11. Chen H, Wang L, Yeh J, Wu X, Cao Z, Wang YA, Zhang M, Yang L, Mao H: Reducing non-specific binding and uptake of nanoparticles and improving cell targeting with an antifouling PEO-b-P-gamma-MPS copolymer coating, Biomaterials, 2010, 31(20): 5397-5407. (引用次数: 53, Journal impact factor:8.56)
12. Galanzha E, Shashkov EV, Kelly T, Kim JW, Yang L and Zharov VP. In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumor cells. Nature Nanotechnology, 2009; 4 (12):855-860. (引用次数: 308, Journal impact factor:41.5)
13. Yang L, Peng XH, Wang YA, Wang X, Cao Z, Ni C, Karna P, Zhang X, Wood WC, Gao X, Nie S and Mao H. Receptor-targeted nanoparticles for in vivo imaging of breast cancer. Clinical cancer Research, 2009, 15(14): 4722-4732.(引用次数: 193, Journal impact factor: 9.6)
14. Yang L, Mao H, Cao Z, Wang YA, Peng X, Wang X, Sajja H, Duan H, Ni C, Staley CA, Wood WC, Gao X, and Nie S. Molecular imaging of pancreatic cancer in an animal tumor model using targeted multifunctional nanoparticles. Gastroenterology 2009, 136(5): 1514-1525. (引用次数: 128, Journal impact factor:18.2)
15. Yang L, Mao H, Wang YA, Cao Z, Peng X, Wang X, Duan H, Ni C, Wood WC, Gao X, and Nie S. Single chain epidermal growth factor receptor antibody conjugated nanoparticles for in vivo tumor targeting and imaging. Small 2009, 5(2):235-243. (引用次数:311, Journal impact factor:8.37)
16. Qian XM, Peng XH, Ansari D. Yin-Goen Q, Shin DM, Yang L, Young AN and Nie S. In-vivo tumor targeting and spectroscopic detection with surface-enhanced raman nanoparticle tags. Nature Biotechnology, 2008, 26(1):83-90. (引用次数:1693,Journal impact factor:41.5)
17. Wang X, Yang L, Chen G, Shin DM. Application of Nanotechnology in Cancer Therapy and Imaging. CA: A Cancer Journal for Clinicians, 2008, Vol 58(2). (引用次数: 452,Journal impact factor: 115.9)
18. Han, A, Yang L, and Frazier AB. Quantification of the heterogeneity in breast cancer cell lines using whole cell impedance spectroscopy. Clinical Cancer Research, 2007, Vol. 13, 1, pp. 139-143. (引用次数:130,Journal impact factor: 8.72)
19. Rhyner MN, Smith AM, Gao X, Mao H, Yang L and Nie S. Quantum dots and multifunctional nanoparticles: new contrast agents for tumor imaging. Nanomedicine, 2006, 1(2), 209-217. (引用次数:193,Journal impact factor:5.41)
20. Peng X, Karna P, Cao Z, Jiang B, Zhou M, and Yang L. Cross-talk between epidermal growth factor receptor and HIF-1 signal pathways increases resistance to apoptosis by upregulating survivin gene expression. Journal of Biological Chemistry, 2006, (36):25903-25914.(引用次数:274,Journal impact factor:4.57)
21. Peng XH, Cao ZH, Xia JT, Carlson W. G, Lewis MM, Wood, WC and Yang L*, Real-time detection of gene expression in cancer cells using molecular beacon imaging: New strategies for cancer research. Cancer Research, 2005, 65 (5), 1909-1917. (引用次数:105,Journal impact factor: 9.33)
22. Gao X, Yang L, Petros J, Marshall FF, Simons JW and Nie S. In vivo molecular and cellular imaging with quantum dots. Current Opinion in Biotechnology, 2005, 16:63-78 (引用次数:1118,Journal impact factor:8.04)
23. Yang L, Cao ZH, Yan H and Wood WC. Co-existence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: Implication for cancer specific therapy. Cancer Research, 2003, 63: 6815-6824. (引用次数:218, Journal impact factor: 9.3)
三、受聘后的预期工作目标(主要填写履行本岗位职责的工作思路;受聘期间年度岗位工作任务等,将纳入聘任合同。)
(一)教学任务
1.每年举办2次本学科世界前沿学术讲座
(二)科研任务
1.聘期内协助科研团队科研人员申请国家自然科学基金项目1-2项。
(三)人才培养、学科建设等
医学学术团队建设,培养3-4名青年骨干教学科研人才
(四)科学合作与国际交流
1.协助促进杭州师范大学整合药学院与美国高水平医学实验室交流互访。
3.协助杭州师范大学整合药学院与美国爱默蕾大学联合培养硕士和博士。