侯书荣 博士， 副教授

1985年5月出生于安徽宿州，2008年获得中国科学院大学分析化学硕士学位，2014年获得美国肯塔基大学药学博士学位，2015年于美国Scripps研究所药物分子筛选中心从事博士后研究，2018年9月进入杭州师范大学医学院整合药学院工作。先后共发表SCI论文27篇，其中一作9篇，包括Oncogene，Oncotarget，Biochemical Journal，Organic & Biomolecular Chemistry等。

教育与工作经历：

2018.9- 杭州师范大学 医学院整合药学院 副教授

2015.3-2018.9 美国Scripps研究所 药物筛选 博士后 

2010.1-2014.8 美国肯塔基大学 药学专业 博士

2005.9-2008.7 中国科学院大学 分析化学专业 硕士

2001.9-2005.7 安徽师范大学 化学专业 学士

研究领域与方向：

（1）基于计算机辅助药物设计的蛋白药物发现与功能改造。

（2）基于高通量药物筛选的抗肿瘤药物研发及相关机理研究。

代表文章

1. Smitha Kota, Shurong Hou# (co-first authors), William Guerrant, Franck Madoux, Scott Troutman, Virneliz Fernandez-Vega, Nina Alekseeva, Neeharika Madala, Louis Scampavia, Joseph Kissil, Timothy P. Spicer.  “A novel three-dimensional high-throughput screening approach identifies inducers of a mutant KRAS selective lethal phenotype”. Oncogene, 2018, 37: 4372-4384.

2. Shurong Hou, Hervé Triac, Banu Priya Sridharan, Louis Scampavia, Franck Madoux, Jan Seldin, Glauco R. Souza, Donald Watson, David Tuveson and Timothy Spicer. “Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening”. SLAS DISCOVERY: Advancing Life Sciences R&D, 2018, 23(6): 574-584.

3. Robert A. Wolff, Andrea Wang-Gillam, Hector Alvarez, Hervé Tiriac, Dannielle Engle, Shurong Hou# (co-first authors), Abigail F. Groff, Anthony San Lucas, et.al. “Dynamic changes during the treatment of pancreatic cancer”. Oncotarget, 2018, 9:14764-14790.

4. Victor Quereda, Shurong Hou# (co-first authors), Franck Madoux, Louis Scampavia, Timothy Spicer, Derek Duckett. “A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem Cells”. SLAS DISCOVERY: Advancing Life Sciences R&D, 2018, 23(8): 842-849 

5. Shurong Hou, Franck Madoux, Louis Scampavia, Jo Ann Janovick, P Michael Conn, Timothy P Spicer. “Drug Library Screening for the Identification of Ionophores That Correct the Mistrafficking Disorder Associated with Oxalosis Kidney Disease”. SLAS DISCOVERY: Advancing Life Sciences R&D, 2017, 22(7): 887-896.

6. Shurong Hou, Max Zhan, Xirong Zheng, Chang-Guo Zhan, Fang Zheng. “Kinetic Characterization of Human Butyrylcholinesterase Mutants for the Hydrolysis of Cocaethylene”. Biochemical Journal, 2014, 460: 447-457.

7. Shurong Hou, Liu Xue, Wenchao Yang, Lei Fang, Fang Zheng, and Chang-Guo Zhan. “Substrate Selectivity of High-activity Mutants of Human Butyrylcholinesterase”. Organic & Biomolecular Chemistry, 2013, 11(43): 7477-7485.

8. Liu Xue, Shurong Hou# (co-first authors), Wenchao Yang, Lei Fang, Fang Zheng, and Chang-Guo Zhan. “Catalytic Activities of a Cocaine Hydrolase Engineered from Human Butyrylcholinesterase against (+)- and (−)-Cocaine”. Chemico-Biological Interactions, 2013, 203 (1): 57-62. 

9. Shurong Hou, Na Zheng, Haiyan Feng, Xiangjun Li and Zhuobin Yuan. “Determination of Dopamine in the Presence of Ascorbic Acid using Poly(3,5-dihydroxy benzoic acid) Film Modified Electrode”. Analytical Biochemistry, 2008, 381(2): 179-184.

10. Kai Ding, Ziyuan Zhou, Shurong Hou, Yaxia Yuan, Shuo Zhou, Xirong Zheng, Jianzhong Chen, Charles Loftin, Fang Zheng, Chang-Guo Zhan. “Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs” Scientific Reports, 2018, 8: 5205.

11. Xiabin Chen, Liu Xue, Shurong Hou, Zhenyu Jin, Ting Zhang, Fang Zheng, Chang-Guo Zhan. “Long-acting cocaine hydrolase for addiction therapy”. Proceedings of the National Academy of Sciences, 2016, 113(2): 422-427.

12. Fang Zheng, Liu Xue, Shurong Hou, Junjun Liu, Max Zhan, Wenchao Yang, Chang-Guo Zhan. “A Highly Efficient Cocaine-detoxifying Enzyme Obtained by Computational Design”. Nature Communications, 2014, 5: 3457.

13. Lei Fang, Martin Chow, Shurong Hou, Liu Xue, Xiabin Chen, David Rodgers, Fang Zheng, Chang-Guo Zhan. “Rational Design, Preparation and Characterization of a Therapeutic Enzyme Mutant with Improved Stability and Function for Cocaine Detoxification”. ACS Chemical Biology, 2014, 9(8): 1764-1772. 

14. Lei Fang, Shurong Hou, Liu Xue, Fang Zheng, Chang-Guo Zhan. “Amino-acid Mutations to Extend the Biological Half-life of a Therapeutically Valuable Mutant of Human Butyrylcholinesterase”. Chemico-Biological Interactions, 2014, 214: 18-25.

15. Max Zhan, Shurong Hou, Chang-Guo Zhan, Fang Zheng. “Kinetic Characterization of High-activity Mutants of Human Butyrylcholinesterase for Cocaine Metabolite Norcocaine”. Biochemical Journal, 2014, 457 (1): 197-206.

16. Liu Xue, Shurong Hou, Min Tong, Lei Fang, Xiabin Chen, Zhenyu Jin, Hsin-Hsiung Tai, Fang Zheng and Chang-Guo Zhan. “Preparation and in vivo Characterization of a Cocaine Hydrolase Engineered from Human Butyrylcholinesterase for Metabolizing Cocaine”. Biochemical Journal, 2013, 453 (3): 447-454.

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