刘水平 博士
一、基本信息
刘水平,博士,杭州师范大学医学院,副研究员,药学硕士研究生指导老师。博士毕业后一直致力于胃肠肿瘤细胞分子生物学研究,目前主要研究榄香烯逆转结直肠癌,肺癌等恶性肿瘤细胞耐药的分子机制。已发表SCI论文17篇,其中1作论文8篇,主持国家自然科学基金青年项目和浙江省自然科学基金青年基金项目等4项。联系电话:086-0571-28860233,邮箱: shuipingliu@zju.edu.cn。
二、学习与工作经历
2018/3–至今,杭州师范大学医学院,副研究员
2015/5–2018/3,浙江大学医学院附属邵逸夫医院,助理研究员
2011/9–2015/3,浙江大学,获生物化学与分子生物学博士学位
2008/9–2011/7,南京农业大学,获生物化学与分子生物学硕士学位
三、承担课题
1. 国家自然科学基金青年基金项目,81802371,E3连接酶RNF148调控抑癌基因CHAC2在结直肠癌发生发展中的作用及机制研究,2019/01-2021/12,21万,在研,主持
2. 杭州师范大学科研启动项目,2018QDL013,榄香烯逆转结直肠癌细胞5-FU耐药的分子机制研究,2018/05-2021/04,20万,在研,主持
3. 浙江省医药卫生科技计划面上项目(A类),《RNF148通过泛素化降解CHAC2促进结直肠癌发展的分子机制研究》 2018/01-2020/12,3万,在研,主持
4. 浙江省自然科学基金青年项目,LQ17H160009,CHAC2通过内质网应激反抑制胃肠肿瘤发展的分子机制研究,2017/01-2019/12,6万,在研,主持
四、发表的文章代表
(1) Xueli Li#, Shuiping Liu#, Xiao Fang*, Chao He*, Xiaotong Hu*, The mechanisms of DIRAS family members in role of tumor suppressor, Journal of Cellular Physiology, 2018, 1-14.
(2) Jiaxin Chen#, Shuiping Liu#, Xiaotong Hu*, Long non-coding RNAs: crucial regulators of gastrointestinal cancer cell proliferation, Cell Death Discovery, 2018, 4:50
(3) Shuiping Liu, Weiqiang Fei, Qinglan Shi, Qiang Li, Yeye Kuang, Chan Wang, Chao He, Xiaotong Hu*, CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response, Cell Death & Disease, 2017, 8(8), e3009
(4) Weiqiang Fei#, Shuiping Liu#, Xiaotong Hu*, High FOXRED1 expression predicted good prognosis of colorectal cancer, American Journal of Cancer Research, 2016, 6(11): 2722-2728
(5) Shuiping Liu, Pin Yu, Penghui Yuan, Zhenxing Zhou, Qingting Bu, Xuming Mao, Yongquan Li*. Sigma factor WhiGch positively regulates natamycin production in Streptomyces chattanoogensis L10. Applied Microbiology and Biotechnology, 2015, 99(6): 2715-2726
(6) Shuiping Liu, Penghui Yuan, Yueyue Wang, Xiaofang Liu, Zhenxing Zhou, Qingting Bu, Pin Yu, Hui Jiang and Yongquan Li*. Generation of the natamycin analogs by gene engineering of natamycin biosynthetic genes in Streptomyces chattanoogensis L10. Microbiological Research, 2015, 173: 25-33
(7) Shuiping Liu, Yanping Zhu, Chao Xie, Dengwei Jue, Yongbo Hong, MinChen, Ali Kaleri Hubdar, Qing Yang*, Transgenic potato plants expressing StoVe1 exhibit enhanced resistance to Verticillium dahlia, Plant molecular biology reporter, 2012, 30(4): 1032-1039
(8) Shuiping Liu, Yongbo Hong, Zhen Wu, Yongshuo Ma, Dengwei Jue, Chao Xie, Yanping Zhu, MinChen, Qing Yang*, Protein extract of Tobacco expressing StoVe1 gene inhibits Verticillium dahliae proliferation, Czech journal of genetics and plant breeding, 2013, 49(2): 58-64
(9) Xiaotong Hu, Shuiping Liu. Epigenetic Biomarkers, Handbook of epigenetics: the new molecular and medical genetics, 2017, Academic Press.
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